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There are several enemies She-Hulk has faced in her various solo series, ranging from major villains such as Titania and Man-Elephant, to the less prominent such as Pseudo-Man and the inmates of Dorkham Asylum. She has also battled several villains from other heroes' rogues' galleries, such as Stilt-Man and Mysterio. Villains found on this list include She-Hulk's own villains, as well as villains that aren't primarily She-Hulk's, but ones she's faced on more than one occasion.

In She-Hulk #2, She-Hulk comments that her rogues' gallery consists of Titania, Ultima, and Man-Elephant.

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